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BAY 60–6583
BAY 60–6583 is a selective adenosine A2B receptor agonist.〔Baraldi PG, Tabrizi MA, Fruttarolo F, Romagnoli R, Preti D. Recent improvements in the development of A(2B) adenosine receptor agonists. ''Purinergic Signalling''. 2008 Dec;4(4):287-303. PMID 18443746〕 It has been shown to provide protection from ischemia (lack of oxygen due to blocked blood supply) in both the heart and kidney of test animals,〔Eckle T, Krahn T, Grenz A, Köhler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK. Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. ''Circulation''. 2007 Mar 27;115(12):1581-90. PMID 17353435〕〔Grenz A, Osswald H, Eckle T, Yang D, Zhang H, Tran ZV, Klingel K, Ravid K, Eltzschig HK. The reno-vascular A2B adenosine receptor protects the kidney from ischemia. ''PLoS Medicine''. 2008 Jun 24;5(6):e137. PMID 18578565〕 and has also been shown to be beneficial in treatment of acute lung injury,〔Eckle T, Grenz A, Laucher S, Eltzschig HK. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. ''Journal of Clinical Investigation''. 2008 Oct;118(10):3301-15. PMID 18787641〕 showing a range of potential applications for selective A2B agonists.
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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